Though Phera-Plex cannot convert to estrogen itself, it does have some type of indirect estrogenic activity causing users to experience estrogenic side effects such as water retention under the skin resulting in a bloated look. Because of this, Phera-Plex is typically used for bulking cycles. Like Superdrol, Phera-Plex is an inhibitor of 11-beta hydroxylase, causing water retention within the muscle as well. The rapid gains in water weight with Phera-Plex, make it attractive to those looking to put on instant size and weight. Unfortunately, a large portion of this weight will be lost when use is discontinued and water balance returns to normal. Phera-Plex is methylated to increase oral absorption, and as a result of this it is fairly liver toxic. Other possible side effects include bad lipid profiles, gynecomastia (another estrogenic side effect), and painful cramping and pumps, especially in the lower back and calves.