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Interleukin 1 (IL-1) and tumor necrosis factor (TNF) are integral components to the cell mediated immune response to injury. The expression of these cytokines can be effectively inhibited by corticosteroids 8 IL-1 originates from macrophages, monocytes and various parenchymal cells and induce the production of endothelial based proteins. This results in thrombus formation and ultimately the activation of inflammatory and immune cells. IL-1 also affects procoagulant proteins, adhesive factors and the metabolism of arachidonic acid within the endothelial cell. TNF stimulates the production of various chemotactic mechanisms from neutrophils and granulocytic proteins.