Although patients receiving systemic corticosteroid therapy are more susceptible to secondary infection than patients not receiving corticosteroids, administration via the inhaled route minimizes this risk. Corticosteroid therapy can mask the symptoms of infection and should not be used in cases of bacterial, fungal, or viral infections that are not adequately controlled by anti-infective agents, except in life-threatening circumstances. Fluticasone; salmeterol should be avoided in patients with tuberculosis infections of the respiratory tract if possible. The incidence or course of acute bacterial or viral infection is probably minimally affected by inhaled corticosteroids in immunocompetent individuals; however, close monitoring of patients with immunosuppression is recommended if treatment with an inhaled corticosteroid is necessary.
Yes. When compared to using an inhaled steroid alone or an inhaled bronchodilator ( albuterol ) alone, combination therapy significantly improves some outcomes. Symbicort has collected more data on teens and adolescents with asthma but all three of these inhalers work better than placebo in folks with asthma and COPD. There aren’t many comparisons for us to know which of these three inhalers is best but in one head to head study Symbicort edged out Advair in reducing hospitalizations and ER visits in people older than 16 with asthma.