The human genome includes five non-allelic genes that encode for five or six distinct transmembrane domain G-protein-coupled SSTRs (somatostatin receptors). The gene encoding SSTR2 produces two splice variants (SSTR2A and SSTR2B) in mouse and presumably in humans as well [ 35 - 38 ], whereas the other genes are intronless and generate one receptor in each case [ 39 - 42 ]. The natural ligands of SSTR1-5 (SST-14, SST-28 and cortistatin) are bound with a high affinity. Nevertheless the majority of (longer acting) synthetic peptide analogues, namely MS201-995 (octreotide), RC-160 (vapreotide), BIM 23014 (lanreotide) and MK 678 (Seglitide), only interact with the subtypes SSTR 2, 3 and 5 to a satisfactory extent. Moreover, Pasireotide (SOM 230) shows higher binding capacity towards SSTR1 [ 43 , 44 ].
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