Danazol is metabolized in the liver by enzymes such as CYP3A4 .   Its elimination half-life has varied across studies, but has been found to be 3 to 10 hours after a single dose and 24 to 26 hours with repeated administration.   The major metabolites of danazol are 2-hydroxymethylethisterone (also known as 2-hydroxymethyldanazol; formed by CYP3A4 and described as inactive) and ethisterone (a progestogen and androgen),     and other, minor metabolites include δ 2 -hydroxymethylethisterone, 6β-hydroxy-2-hydroxymethylethisterone, and δ 1 -6β-hydroxy-2-hydroxymethylethisterone.  At least 10 different metabolites have been identified.  Danazol is eliminated in urine and feces , with the two primary metabolites in urine being 2-hydroxymethylethisterone and ethisterone. 
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