Mineralocorticosteroid deficiency

The external ear should be thoroughly cleaned and dried before treatment. Remove foreign material, debris, crusted exudates, etc., with suitable non-irritating solutions. Excessive hair should be clipped from the treatment area. After verifying that the eardrum is intact, instill 4 drops from the g and 15 g tube, and 15 g and 30 g bottle (2 drops from the 215 g bottle) of OTOMAX ointment twice daily into the ear canal of dogs weighing less than 30 lbs. Instill 8 drops from the g and 15 g tube, and 15 g and 30 g bottle (4 drops from the 215 g bottle) twice daily into the ear canal of dogs weighing 30 lbs or more. Massage external ear canal carefully after instillation to ensure appropriate distribution of medication. Therapy should continue for 7 consecutive days.

Athletes, like all others, may have illnesses or conditions that require them to take particular medications. If the 
medication an athlete is required to take to treat an illness or condition happens to fall under the prohibited list, a therapeutic use exemption may give that athlete the authorization to take the needed medicine. Criteria for granting a therapeutic use exemption are 1.) The athlete would experience significant health problems without taking the prohibited substance or method, 2.) The therapeutic use of the substance would not produce significant enhancement of performance, and 3.) There is no reasonable therapeutic alternative to the use of the otherwise prohibited substance or method. Note hormone replacement therapy (HRT), . supplementing with prescribed testosterone in any form to raise testosterone levels due to natural decreases that occur with aging (even if to just elevate levels to within ‘normal’ ranges), is NOT considered a medicinal exception. Persons using HRT would not be eligible for WPA/NANBF/IPE competition.

Fludrocortisone .  Fludrocortisone is a mineralocorticosteroid that appears to be effective for most types of postural hypotension, or low blood pressure. It works by promoting sodium retention by the kidney , thereby causing fluid retention and some swelling , which is necessary to improve blood pressure. But this sodium retention also causes a loss of potassium. So when taking fludrocortisone, it's important to get adequate amounts of potassium each day. Fludrocortisone has none of the anti-inflammatory properties of cortisone and  prednisolone and is not a muscle-building agent.

In vitro , clotrimazole exhibits fungistatic and fungicidal activity against isolates of Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis, Candida spp. and Malassezia pachydermatis (Pityrosporum canis) . Resistance to clotrimazole is very rare among the fungi that cause superficial mycoses. In an induced otitis externa infected with Malassezia pachydermatis , 1% clotrimazole in the gentamicin-betamethasone-clotrimazole ointment vehicle was effective both microbiologically and clinically in terms of reduction of exudate odor and swelling.

Mineralocorticosteroid deficiency

mineralocorticosteroid deficiency

In vitro , clotrimazole exhibits fungistatic and fungicidal activity against isolates of Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis, Candida spp. and Malassezia pachydermatis (Pityrosporum canis) . Resistance to clotrimazole is very rare among the fungi that cause superficial mycoses. In an induced otitis externa infected with Malassezia pachydermatis , 1% clotrimazole in the gentamicin-betamethasone-clotrimazole ointment vehicle was effective both microbiologically and clinically in terms of reduction of exudate odor and swelling.

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