As several people on here have mentioned in the comments some border collies are sensitive to this product. From what I have read in the past, ALL breeds of collies may have a gene that makes them sensitive to Ivermectin, a common heartworm preventative. Other herding breeds such as the GSD are also reported to have this gene. However in GSDs it is much lower, only about 10% of them have it. If you are concerned I would recommend talking to your vet, there are also tests they could take to see if your dog carries this gene. However after reading about this product it says it uses imidacloprid and moxidectin as the active ingredients. I do not know the effects of these ingredients on herding breeds.
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