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Topical OTC 1% hydrocortisone can significantly help common baby skin conditions such as mild flare ups of eczema, drool rash, baby acne, cradle cap, and bug bite reactions. Because it is an anti-inflammatory agent, it can provide relief for itchy, uncomfortable babies. However, before using an OTC 1% hydrocortisone cream, talk with your doctor and make sure it’s safe for your baby. And remember, hydrocortisone is a medicine, and while medicines are amazing and have made tremendous progress over the years, there are still risks associated with them. The bottom line: is hydrocortisone cream safe for babies? Yes. Just be sure to keep talking with your doctor and use them as directed.