Steroid hormones act by binding to receptors that are located where

Cells of the zona fasciculata and zona reticularis lack aldosterone synthase (CYP11B2) that converts corticosterone to aldosterone, and thus these tissues produce only the weak mineralocorticoid corticosterone. However, both these zones do contain the CYP17A1 missing in zona glomerulosa and thus produce the major glucocorticoid, cortisol. Zona fasciculata and zona reticularis cells also contain CYP17A1, whose 17,20-lyase activity is responsible for producing the androgens, dehydroepiandrosterone (DHEA) and androstenedione. Thus, fasciculata and reticularis cells can make corticosteroids and the adrenal androgens, but not aldosterone.

All bets are off the table when high-dose testosterone and its many metabolites are used illegally, such as with anabolic steroid abuse. Strokes, embolisms, and cardiovascular disease are all more likely, as is sudden death, and liver and kidney disease. 44 In women, acne, irreversible deepening of the voice, baldness, increased facial hair, enlarged sex organs, breast reduction, depression, and infertility have all been reported. In adult men that abuse anabolic steroids, acne, baldness, permanent infertility, gynecomastia, loss of libido, erectile dysfunction, testicle shrinkage, and profuse sweating are all reported side effects. Increased testicular cancer hasn't been reported, though. 45,46

* These products are not intended to diagnose, treat, cure or prevent any disease. These statements have not been evaluated by the Food and Drug Administration (FDA). This website and the associated domain names "roid-" are representative of ingredients which may enhance blood levels of hormones in the body. This site is offering this extremely strong alternative to the highly toxic drug listed on the top of the page. These products are not drugs. Our products are not to be used by anyone under 18 years of age. The information provided on this site is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem.

Erythropoietin (EPO): A 165 amino acid glycoprotein hormone (glycoproteins consist of several sugar molecules linked with a protein molecule). EPO stimulates erythrocyte (red blood cell) production in the bone marrow, boosting the blood's ability to carry oxygen. Studies have shown that significant amounts of EPO resist digestion and survive to reach receptors in the intestinal tract. One raw milk-drinking athlete was wrongly accused of blood-doping, so there's at least anecdotal evidence of EPO's activity in our systems!

Steroid hormones act by binding to receptors that are located where

steroid hormones act by binding to receptors that are located where

Erythropoietin (EPO): A 165 amino acid glycoprotein hormone (glycoproteins consist of several sugar molecules linked with a protein molecule). EPO stimulates erythrocyte (red blood cell) production in the bone marrow, boosting the blood's ability to carry oxygen. Studies have shown that significant amounts of EPO resist digestion and survive to reach receptors in the intestinal tract. One raw milk-drinking athlete was wrongly accused of blood-doping, so there's at least anecdotal evidence of EPO's activity in our systems!

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