Steroid transformation ppt

Depending on the number and character of their functional groups, steroid molecules may show diverse reactivities. Moreover, the reactivity of a functional group varies according to its location within the molecule (for example, esters are formed readily by 3-OH groups but only with difficulty by the 11β-OH group). An important property of steroids is polarity —., their solubility in oxygen-containing solvents (., water and alcohols ) rather than hydrocarbon solvents (., hexane and benzene ). Hydroxyl, ketonic, or ionizable (capable of dissociating to form electrically charged particles) groups in a steroid molecule increase its polarity to an extent that is strongly influenced by the spatial arrangement of the atoms within the molecule.

I had a son who had a lot of dental work done a few years back. He had 2 terribly infected molars which we pulled out and used the wisdom teeth in place of them. My orthodondist assured me it can be done on the top teeth. Through the whole process I used Young Living oils in capsuls for pain, rubbed the foot points for teeth and used a natural socket gel my dentist gave us after the treatment for a few days. I never filled or had him take any prescription or antibiotics for removing these infected molars or his bottom wisdom teeth that were pulled a year or so later. It was stressful for me to take this on, as I had never used oils for this situation before. I knew I needed to do my best with everything I have learned over the past 10 years. My dentist also has a healing laser which he used to speed up the healing. My son was jumping on the trampoline with no bleeding the morning after getting his molars pulled. I was shocked and amazed!

Intravenously administered glucocorticoids , such as prednisone , are the standard of care in acute GvHD [7] and chronic GVHD. [24] The use of these glucocorticoids is designed to suppress the T-cell-mediated immune onslaught on the host tissues; however, in high doses, this immune-suppression raises the risk of infections and cancer relapse. Therefore, it is desirable to taper off the post-transplant high-level steroid doses to lower levels, at which point the appearance of mild GVHD may be welcome, especially in HLA mis-matched patients, as it is typically associated with a graft-versus-tumor effect. [ citation needed ] . Cyclosporine and tacrolimus are inhibitors of calcineurin. Both substances are structurally different but have the same mechanism of action. Cyclosporin binds to the cytosolic protein Peptidyl-prolyl cis-trans isomerase A (known as cyclophilin), while tacrolimus binds to the cytosolic protein Peptidyl-prolyl cis-trans isomerase FKBP12. These complexes inhibit calcineurin, block dephosphorylation of the transcription factor NFAT of activated T-cells and its translocation into the nucleus. [25] Standard prophylaxis involves the use of cyclosporine for six months with methotrexate. Cyclosporin levels should be maintained above 200 ng/ml. [26] Other substances that have been studied for GvHD prophylaxis include, for example: sirolimus, pentostatin and alemtuzamab. [26]

Steroid transformation ppt

steroid transformation ppt


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