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One recent randomized controlled trial showed a significant reduction in IVH with antenatal corticosteroid treatment. Secondary outcome variables reported in the meta-analysis of randomized controlled trials also showed a significant reduction in the incidence of IVH with an odds ratio of (95% CI -). This reduction in IVH is supported by the results of the observational database, information prospectively collected in five registries involving more than 30,000 low-birthweight infants. Since IVH is an important contributor to mortality and serious long-term neurodevelopmental disability, this reduction is a major benefit.

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