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Tamoxifen decreases cell division in oestrogen-dependent tissues. In metastatic breast cancer, partial or complete remissions were observed in 50-60% of cases, particularly in bone and soft tissue metastases if oestrogen-receptors were found in the tumour. In cases of negative hormone-receptor status, particularly of the metastases only approx. 10% showed objective remissions. Women with oestrogen receptor-positive tumours or tumours with unknown receptor status who received adjuvant treatment with tamoxifen experienced significantly less tumour recurrences and had a higher 10-year survival rate. The effect was greater after 5 years of adjuvant treatment compared with 1-2 years of treatment. The benefit appears to be independent of age, menopausal status, daily tamoxifen dose and additional chemotherapy.
Of all the SERM’s on the market, and there are quite a few, Tamoxifen Citrate is perhaps the most valuable and beneficial. For the breast cancer patient it can almost be labeled as an imperative medication; in fact, in many cases we can call it life saving or at least a major part of an overall life saving plan. For the steroid user, it’s really not the best thing since sliced bread when it comes to on cycle use, but it can serve a p urpose for some. It is during PCT that the steroid user will find this product highly valuable. In fact, if the Nolvadex and Clomid combo cannot be used and you could only pick one SERM for your PCT recovery, undoubtedly Tamoxifen Citrate would be the way to go.